2-color ultrafast laser source (credit: Jesse Wilson).
We develop advanced microscopy techniques to provide contrast between cell and tissue components that are difficult to resolve with traditional stains and dyes. We do this by leveraging the physics of light-matter interactions, incorporating nonlinear optics and real-time digital signal processing techniques. Currently pursuing applications in the areas of mitochondrial function and disease, melanoma and skin cancer detection. The tools we employ are nonlinear and ultrafast optics, sub-picosecond time-resolved optical interactions such as transient absorption, real-time digital signal processing, and deep learning with convolutional networks and generative-adversarial networks.
2-color ultrafast laser source (credit: Jesse Wilson).
Simultaneous reflectance confocal and second harmonic generation imaging of canine oral mucosa. Depth encoded by false color (credit: Arya Mugdha).
Congratulations to Dave Smith for passing his Ph.D. defense! (June 2024)
Congratulations to Priya Wolff for receiving a Scholar's Year Award through the University of Colorado School of Medicine Program to Advance Physician Scientists and Translational Research! (March 2024)
Congratulations to Cameron Coleal for passing her Ph.D. defense! (March 2024)
Congratulations to Mikyla Bowen for receiving a Boettcher Educational Enrichment Grant!
Our work on image2image networks and melanoma detection has been featured in a News Update at the Melanoma Research Alliance (November 2023).
Congratulations to Erkang Wang for passing his Ph.D. defense and starting a new job!
Congratulations to Mikyla Bowen for winning 1st place in Excellence in Data Science Research at the 2022 CSU Celebrate Undergraduate Research and Creativity Showcase, for her work in image2image convolutional networks!
Our recent paper on adaptive noise cancelling with an FPGA has been featured on the Red Pitaya Blog (July 2021).
SPIE Digital Library Hits Half-a-Million Milestone (Dave Smith's conference presentation mentioned as the 500,000th presentation on SPIE Digital Library).
CCTSI pilot awardee uses virtual biopsies to improve melanoma detection (Wendy S. Meyer, Found in Translation, Fall 2018).
Boettcher Investigator grant recipient studies mitochondrial diseases (Rocky Mountain Collegian, Sept 12 2018)
Using virtual biopsies to improve melanoma detection (Colorado State University SOURCE, May 18, 2018)
(unpaid) Currently looking for an M.S. student (Plan B Project) for a project in physics-informed machine learning and optical pulse reconstruction (see conference paper below on ultrafast pulse retrieval)
(unpaid) Currently looking for an M.S. student (Plan B Project) for a project in nonlinear optics, simulating self-phase modulation and spectral broadening with recurrent convolutional networks.
Last updated 2024-03-14. Contact Prof. Wilson for more details.
"Transient absorption spectroscopy and imaging of redox in muscle mitochondria." (2022) Biomedical Optics Express. (*Featured in the 15 Top-Downloaded Papers on Tissue Optics and Spectroscopy in Biomedical Optics Express, Dec. 2023.)
"Phase noise limited frequency shift impulsive Raman spectroscopy." (2021) APL Photonics.
"Adaptive noise canceling for transient absorption microscopy." (2020) Journal of Biomedical Optics.
"Multifrequency microfluidic impedance cytometer using a field-programmable gate array for parasite egg analysis." (2020) Biomedical Sciences Instrumentation.
"Invited Review Article: Pump-probe microscopy." (2016) Review of Scientific Instruments.
"Ultrafast pulse retrieval with one-shot unsupervised deep learning." (2023)
"Real-Time Time-Resolved Optical Measurements using a Digital Adaptive Filter." (2018)
Arya Mugdha, Graduate Research Assistant.
William Hudson, Volunteer / Engineer in Residence.
Priya Wolff, University of Colorado School of Medicine Scholar.
Samuel Hero, Undergraduate Data Science Researcher.
Jesse Wilson, Assistant Professor. (Google Scholar Profile)
Dave Smith, Ph.D.
Mikyla Bowen, Boettcher Scholar Undergraduate Researcher.
Tai Ngo, Undergraduate Researcher
Cameron Coleal, Ph.D.
Luke Shuttleworth, Scott Undergraduate Researcher
Erkang Wang, Ph.D. (Google Scholar Profile)
Gabrielle Liferth, Undergraduate Researcher.
Saurabh Gupta, Graduate Research Assistant.
Servando Calderon, Undergraduate Catalyst Researcher.
Nathan You, Undergraduate Researcher.
Justin Falk, Undergraduate Honors Researcher.
Ava Raymond, Undergraduate Honors Researcher.
Namratha Menon, Volunteer VLSI Developer.
Ben Jenkins, Graduate Project Student.
Xuefei Chen, Graduate Project Student.
Dr. Scott Domingue.
Ming-Hao Cheng.
Alyssia Dong
Swarnava Pramanik
Ayush Mittal
jesse(dot)wilson(at)colostate(dot)edu
Last updated: 3/14/2024