Cardiovascular disease (CVD), including heart disease and stroke, is a leading cause of death in the US (accounting for one of every three deaths). Presently the US spends >$1 billion each day on CVD. The medical cost is predicted to further increase in the next couple of decades due to increased diabetes, hypertension and aging population.

CVD is associated with local (e.g., arterial stiffening) or global (e.g. blood pressure elevation) biomechanical changes in our body. My research aims to investigate the biomechanics and mechanobiology of cardiovascular tissues in CVD development using state-of-the-art ex vivo tissue and organ mechanical testing systems as well as other interdisciplinary means (medical imaging, microscopic imaging, cardiac physiology, biology, genetics, tissue engineering and etc.).

Current Research Topics

  • Cardiac biomechanics
  • Tissue engineering
  • Vascular biomechanics
  • Stem cell therapy for right heart failure
  • Viscoelasticity