Wilson Lab: Signal Processing and Nonlinear Microscopy

We develop advanced microscopy techniques to provide contrast between cell and tissue components that are difficult to resolve with traditional stains and dyes. We do this by leveraging the physics of light-matter interactions, incorporating nonlinear optics and real-time digital signal processing techniques.


SPIE Digital Library Hits Half-a-Million Milestone (Dave Smith's conference presentation mentioned as the 500,000th presentation on SPIE Digital Library).

CCTSI pilot awardee uses virtual biopsies to improve melanoma detection (Wendy S. Meyer, Found in Translation, Fall 2018).

Boettcher Investigator grant recipient studies mitochondrial diseases (Rocky Mountain Collegian, Sept 12 2018)

Using virtual biopsies to improve melanoma detection (Colorado State University SOURCE, May 18, 2018)


"Transient absorption imaging of hemes with 2-color, independently tunable visible-wavelength ultrafast source." (2017) Biomedical Optics Express.

"Invited Review Article: Pump-probe microscopy." (2016) Review of Scientific Instruments.

Conference Papers and Presentations

"High-sensitivity detection of Raman vibrations in the impulsive limit with Doppler Raman spectroscopy." (2019; Video recording available)

"Real-Time Time-Resolved Optical Measurements using a Digital Adaptive Filter." (2018)

"Pump-probe spectroscopy and imaging of heme proteins: temperature effects and data analysis." (Video recording available)

"Pump-probe microscopy of respiratory chain pigments: towards non-fluorescent label-free metabolic imaging." (Video recording available)

"Real-time digital signal processing in multiphoton and time-resolved microscopy." (Video recording available)

Current Members

Dave Smith, Graduate Research Assistant.

Erkang Wang, Graduate Research Assistant.

Arya Mugdha, Graduate Research Assistant.

Saurabh Gupta, Graduate Research Assistant.

Justin Falk, Undergraduate Honors Researcher.

William Hudson, Volunteer / Engineer in Residence.

Jesse Wilson, Assistant Professor. (Google Scholar Profile)

Past Members

Namratha Menon, Volunteer VLSI Developer.

Ben Jenkins, Graduate Project Student.

Xuefei Chen, Graduate Project Student.

Dr. Scott Domingue.

Ming-Hao Cheng.

Alyssia Dong

Swarnava Pramanik

Ayush Mittal



Last updated: 3/13/2019